American and Chinese scientists have identified how a multi-functional enzyme works to fight diseases including HIV infection and autoimmune disorders.
The study, published in the journal Proceedings of the National Academy of Sciences, has detailed how the enzyme called “SAMHD1” managed to inhibit proteins that stimulate the immune response in human and mouse cells.
SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in dendritic cells, macrophages and monocytes.
This, they said, opens up the possibility of finding ways to turn this activity on and off and making way for new therapeutic approaches for hard-to-treat diseases.
The paper’s senior author Wu Li, a professor in Ohio State University’s Centre for Retrovirus Research, and colleagues from China’s Wuhan University, have illuminated the way in which “SAMHD1” act as a…
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